Product Description
PE-22-28 | 10mg
Researching Mood and Neuroplasticity
What It Does
PE-22-28 is a synthetic peptide derived from spadin, a natural brain fragment involved in mood regulation. It works by blocking the TREK-1 potassium channel, a switch that sets how easily neurons fire, and quieting that channel makes mood- and plasticity-linked circuits more responsive. Studies suggest this produces rapid antidepressant-like activity along with neuroplasticity markers such as BDNF, CREB activation, and new neuron growth in the hippocampus.
What Researchers Study It For
- Rapid antidepressant-like effects
- Blocking TREK-1 potassium channels
- Supporting hippocampal neurogenesis
- Boosting BDNF and neuroplasticity
- Promoting CREB activation and synaptogenesis
Technical Background
PE-22-28 is a synthetic heptapeptide engineered from residues 22-28 of spadin, classified as a selective TREK-1 potassium-channel inhibitor. No completed human efficacy trials exist. Supplied strictly for laboratory research use only.
99%+ HPLC-verified purity. For research use only.