Product Description
LL37 | 5mg
Researching Immune Defense and Antimicrobial Activity
What It Does
LL-37 is a naturally occurring antimicrobial peptide being studied for its role in immune defense and inflammatory regulation. It is a focus in research exploring broad-spectrum antimicrobial activity, immune system signaling, and tissue repair processes.
What Researchers Explore
- Broad-spectrum antimicrobial mechanisms
- Immune system activation and regulation
- Wound healing and tissue repair pathways
- Biofilm disruption in chronic infection models
- Inflammatory response modulation
- Host defense peptide activity
Technical Background
LL-37 is a 37-amino acid antimicrobial peptide (LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES) derived from the human cathelicidin precursor CAP-18. It is amphipathic and carries a net positive charge, enabling interaction with negatively charged microbial membranes.
Research indicates LL-37 disrupts microbial cell membranes directly and also modulates immune responses through pathways involving toll-like receptors (TLRs) and formyl peptide receptors. Structural studies have shown its ability to form α-helical and oligomeric configurations, contributing to its broad-spectrum activity.
Common Research Applications
- Antimicrobial membrane disruption studies
- Endotoxin binding and neutralization research
- Biofilm degradation and prevention models
- TLR and immune signaling pathway research
- Immune cell recruitment and differentiation studies
- Tissue repair and wound healing research
Product Properties
Purity: 99%+ HPLC
Form: Lyophilized Powder
Size: 10mg
Category: Immune / Antimicrobial Research
Frequently Studied Together
- Thymosin Alpha-1 (immune modulation research)
- KPV (anti-inflammatory peptide research)
- ARA-290 (tissue protection and inflammation research)