Product Description
KPV | 10mg
Researching Immune Modulation and Inflammatory Balance
What It Does
KPV is a short peptide derived from a natural immune-signaling molecule and is being studied for its ability to modulate inflammation without broadly suppressing immune function. It is a focus in research exploring gut health, barrier integrity, and inflammatory signaling pathways.
What Researchers Explore
- Reduction of inflammatory signaling pathways
- Immune modulation without suppression
- Gut barrier function and integrity
- Epithelial repair and regeneration
- Anti-inflammatory pathway activity
- Intestinal and skin-related inflammation models
Technical Background
KPV (Lys-Pro-Val) is a tripeptide fragment derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (alpha-MSH), with a molecular weight of 400.48 Da. It has demonstrated comparable or greater anti-inflammatory activity than the full-length peptide.
Research indicates KPV interacts with melanocortin receptors (MC1R and MC3R) and inhibits NF-κB signaling, leading to reduced expression of pro-inflammatory cytokines such as TNF-α and IL-6. Studies also show intestinal uptake via the PepT1 transporter, supporting its role in gut-focused inflammatory research.
Common Research Applications
- NF-κB pathway inhibition research
- Melanocortin receptor signaling studies
- TNF-α and IL-6 modulation research
- Intestinal inflammation and PepT1 transport studies
- Dermatological inflammation research
- Minimal peptide pharmacophore design
Product Properties
Purity: 99%+ HPLC
Form: Lyophilized Powder
Size: 10mg
Molecular Weight: 400.48 Da
Category: Immune / Inflammation Research
Frequently Studied Together
- ARA-290 (tissue protection and inflammation research)
- BPC-157 (tissue repair and gut healing research)
- LL-37 (antimicrobial and immune defense research)