Product Description
IGF-1 LR3 | 1mg
Researching Growth Factor Signaling and Tissue Regeneration
What It Does
IGF-1 LR3 is a long-acting analog of insulin-like growth factor-1 being studied for its role in cellular growth, tissue repair, and anabolic signaling. Unlike upstream growth hormone pathways, it acts directly on muscle and connective tissue, making it a focus in research exploring recovery, regeneration, and cellular development.
What Researchers Explore
- Lean muscle growth and protein synthesis pathways
- Recovery from training stress and injury models
- Tendon, ligament, and joint repair mechanisms
- Nutrient partitioning and metabolic efficiency
- Cellular growth and regeneration signaling
- Physical performance and endurance pathways
Technical Background
IGF-1 LR3 is an 83-amino acid recombinant analog of insulin-like growth factor-1 with a molecular weight of approximately 9,116 Da. It includes an Arg3 substitution and a 13-amino acid N-terminal extension, which reduce binding affinity to IGF binding proteins (IGFBPs), increasing bioavailability and receptor interaction.
These structural modifications extend its half-life to approximately 20–30 hours, compared to 12–15 hours for native IGF-1. It primarily signals through the IGF-1 receptor (IGF-1R), influencing pathways related to cellular growth, differentiation, and repair. Preclinical research has also explored its role in neuroprotection and modulation of inflammatory processes.
Common Research Applications
- Muscle growth and protein synthesis research
- Musculoskeletal injury and regeneration studies
- Neuronal protection and neurodegeneration research
- Extended half-life peptide formulation studies
- Bone growth and osteogenic differentiation research
- IGF-1 receptor signaling and selectivity studies
Product Properties
Purity: 99%+ HPLC
Form: Lyophilized Powder
Size: 1mg
Molecular Weight: 9,116 Da
Amino Acids: 83
Half-Life: 20–30 hours
Modifications: Arg3 substitution and 13 amino acid N-terminal extension
Category: Growth Factor Research
Frequently Studied Together
- CJC-1295 NO DAC + Ipamorelin (growth hormone signaling research)
- Ipamorelin (growth hormone secretagogue research)
- Sermorelin (GHRH analog research)
- Tesamorelin (GH pathway and metabolic research)