Product Description
ACE-031 | 10mg
Researching Muscle Growth, Strength, and Recovery
What It Does
ACE-031 is being studied for its ability to inhibit myostatin, a protein that naturally limits muscle growth. By blocking this pathway, it may allow for increased muscle development and has been explored in research focused on lean mass, strength, and bone density.
What Researchers Explore
- Muscle mass and lean body weight increases
- Bone mineral density improvement
- Muscle strength maintenance
- Age-related muscle loss (sarcopenia)
- Recovery from muscle-wasting conditions
Technical Background
ACE-031 is a soluble ActRIIB-Fc fusion protein (~101–120 kDa) composed of the extracellular domain of activin receptor type IIB linked to a human IgG1 Fc fragment. It functions as a myostatin trap, binding myostatin, activin, and related ligands with high affinity. The Fc component extends circulating half-life to approximately 10–15 days, allowing for sustained systemic exposure. Clinical trials in Duchenne muscular dystrophy demonstrated trends toward preservation of lean body mass but were discontinued due to adverse events.
Common Research Applications
- Myostatin inhibition in muscle-wasting models
- ActRIIB receptor biology research
- TGF-β superfamily signaling studies
- Sarcopenia and age-related muscle loss research
- Fc fusion protein pharmacokinetics
- BMP signaling pathway investigation
Product Properties
Purity: Research Grade
Form: Lyophilized Powder
Size: 10mg
Category: Muscle Growth Research